News Release-- September 14, 2005

FDA Grants Fast Track Designation to DVC Biodefense Vaccine Development Programs

EL SEGUNDO, Calif., Sept. 14 – Computer Sciences Corporation (NYSE: CSC) today announced that DVC LLC, a CSC company, has received Fast Track designation status from the U.S. Food and Drug Administration (FDA) for three biodefense vaccine development programs it is working on for the Department of Defense Joint Vaccine Acquisition Program (JVAP) Product Management Office.

DVC programs to develop recombinant vaccines for plague and botulinum neurotoxin serotypes A and B, and the company’s program to develop a live, attenuated vaccine for Venezuelan equine encephalitis have received the Fast Track designation. Fast Track status allows the FDA to expedite review of drugs and biologics that demonstrate the potential to address unmet medical needs and are intended to treat serious or life-threatening conditions.

“At DVC, our mission is to expedite the development of biodefense products to protect the nation’s operating forces and citizens,” said DVC Chief Scientific Officer Dr. Robert V. House. “We do this by applying for Fast Track status, which enables us to work closely with the FDA to more efficiently meet military biodefense needs.”

JVAP’s mission is to develop, produce and stockpile FDA-licensed vaccine products to protect the warfighter against biological warfare agents. JVAP consolidates Department of Defense efforts for the advanced development, testing, FDA licensing, production and storage of biological defense vaccines.

DVC is a biodefense company dedicated to the development and licensure of safe and efficacious biological products. DVC is part of CSC’s Enforcement, Security and Intelligence organization, which CSC created in 2001 to support programs enhancing U.S. security.

The safety and efficacy of these vaccines in humans has not been established. These products are currently under clinical investigation and have not been licensed by the FDA.

About CSC

Founded in 1959, Computer Sciences Corporation is a leading global information technology (IT) services company. CSC’s mission is to provide customers in industry and government with solutions crafted to meet their specific challenges and enable them to profit from the advanced use of technology.

With approximately 78,000 employees, CSC provides innovative solutions for customers around the world by applying leading technologies and CSC’s own advanced capabilities. These include systems design and integration; IT and business process outsourcing; applications software development; Web and application hosting; and management consulting. Headquartered in El Segundo, Calif., CSC reported revenue of $14.3 billion from continuing operations for the 12 months ended July 1, 2005. For more information, visit the company’s Web site at www.csc.com

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